Publisher Correction: Chromatin analysis in human early development reveals epigenetic transition during ZGA
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چکیده
منابع مشابه
Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescence.
Quiescent lymphocytes have small nuclei, filled with masses of facultative heterochromatin. Upon receiving mitogenic signals, these cells undergo nuclear enlargement, chromatin decondensation, the reactivation of cell proliferation, and changes in the intranuclear positioning of key genes. We examined the levels and intranuclear localization of major histone modifications and non-histone hetero...
متن کاملEpigenetic mechanisms in early mammalian development.
begins well before fertilization because the molecules and controlling mechanisms that direct early development are put in place during oogenesis. The informational content of a mammalian egg at fertilization is not only restricted to its DNA sequence, but also to various DNA and chromatin modifications, specific macromolecules (RNAs and proteins), and possibly the characteristic architecture o...
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Background Cryopreservation of ovarian cortex is increasingly used to preserve fertility before cancer therapy. Recently, studies show that Brain-derived neurotrophic factor (BDNF) may be involved in oocyte maturation. Brain-derived neurotrophic factor (BDNF) is member of neurotrophin family that has anti-apoptotic effects on nervous system. Recent researches show that it also plays key role in...
متن کاملEpigenetic Mechanisms : Chromatin ,
Synopsis Despite the tremendous advances in human genetics enabled by the original public and private human genome projects and brought to fruition with high throughput genotyping and " Nextgen " DNA sequencing, many aspects of human biology still cannot be adequately explained by genetics alone. Normal human development requires the specification of a multitude of cell types/organs that depend...
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Fruit formation and early development involve a range of physiological and morphological transformations of the various constituent tissues of the ovary. These developmental changes vary considerably according to tissue type, but molecular analyses at an organ-wide level inevitably obscure many tissue-specific phenomena. We used laser-capture microdissection coupled to high-throughput RNA seque...
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ژورنال
عنوان ژورنال: Nature
سال: 2018
ISSN: 0028-0836,1476-4687
DOI: 10.1038/s41586-018-0267-z